@article{PB-VRVis-2017-043,
author = {M{\"u}nzing, Sascha E. A. and Strauch, Martin and Truman, James W. and B{\"u}hler, Katja and Thum, Andreas S. and Merhof, Dorit},
title = {larvalign: Aligning Gene Expression Patterns
  from the Larval Brain of Drosophila melanogaster},
year = {2017},
journaltitle = {Neuroinformatics},
doi = {10.1007/s12021-017-9349-6},
url = {https://www.vrvis.at/publications/PB-VRVis-2017-043},
issn = {1559-0089},
abstract = {The larval brain of the fruit fly Drosophila melanogaster is a  small, tractable model system for neuroscience. Genes for  fluorescent marker proteins can be expressed in defined,  spatially restricted neuron populations. Here, we introduce the  methods for 1) generating a standard template of the larval  central nervous system (CNS), 2) spatial mapping of expression  patterns from different larvae into a reference space defined by  the standard template. We provide a manually annotated gold  standard that serves for evaluation of the registration  framework involved in template generation and mapping. A method  for registration quality assessment enables the automatic  detection of registration errors, and a semi-automatic  registration method allows one to correct registrations, which  is a prerequisite for a high-quality, curated database of  expression patterns. All computational methods are available  within the larvalign software package:  https://github.com/larvalign/larvalign/releases/tag/v1.0},
}